Standardization of free thyroxine (FT4) measurements allows the adoption of a more uniform reference interval
Linde A.C. De Grande, Katleen Van Uytfanghe, Dries Reynders, Barnali Das, James D. Faix, Finlay MacKenzie, Brigitte Decallonne, Akira Hishinuma, Bruno Lapauw, Paul Taelman, Paul Van Crombrugge, Annick Van den Bruel, Brigitte Velkeniers, Paul Williams, Linda M. Thienpont
Standaardisatie van schildklierfunctie tests gewenst deel 1
Standaardisatie van schildklierfunctie tests gewenst deel 2
De Grande et al. used the RMP to target the standardization and reference interval (RI) panels, which were also measured by 13 manufacturers. They validated the suitability of the recalibrated results to meet specifications for bias (3.3%) and total error (8.0%) determined from biological variation. However, because these specifications were stringent, they expanded them to 10% and 13%, respectively. The results for the RI panel were reported as if the assays were recalibrated. They estimated all but 1 RI using parametric statistical procedures and hypothesized that the RI determined by the RMP was suitable for use by the recalibrated assays.