Maternal early-pregnancy thyroid function is associated with subsequent hypertensive disorders of pregnancy: The Generation R Study
M Medici,TIM Korevaar, S Schalekamp-Timmermans, R Gaillard, YB de Rijke, WE Visser, W Visser,
SMPF de Muinck Keizer-Schrama, A Hofman, H Hooijkaas, JJ Bongers-Schokking, H Tiemeier, VWV Jaddoe,
TJ Visser, RP Peeters, EAP Steegers
Generation R en de schildklier
The objective of the investigation was to study the associations between early-pregnancy thyroid dysfunction, thyroid function within the normal range, and the risk of hypertensive disorders. In early pregnancy, serum TSH, free T4 (FT4), and thyroperoxidase antibody (TPOAb) levels were determined in 5153 pregnant women. No interventions were done. The associations of thyroid function with the risk of hypertensive disorders were studied. Mean blood pressures and hypertensive disorders, including pregnancy induced hypertension and pre-eclampsia, were measured.