Oogziekte van Graves en Rundle’s curve

It's time to set the record straight on Rundle’s curve. For many years, the term Rundle’s curve has been used as shorthand in the lexicon of Graves ophthalmopathy as a descriptor of the disease’s putative natural history.
Rundle and his curve
GB Bartley
Arch Ophthalmol. 2011;129(3):356-358. doi:10.1001/archophthalmol.2011.29

As depicted the disorder’s signs and symptoms are thought to worsen rapidly during a dynamic phase, reach a point of maximum severity, and then abate to a static plateau that is improved but not resolved to the baseline condition. The curve’s sinuous shape is probably applicable to many other diseases, such as rheumatoid arthritis, as well as to numerous nonmedical phenomena, such as the sales of Beatles’ recordings since 1964 or the waistline of the average American between Thanksgiving and Valentine’s Day.

Rundle’s curve is so widely recognized that it frequently is named without citation. When a reference to F. F. Rundle’s work is provided it almost always is to a publication he coauthored with C. W. Wilson in 1945. Occasionally the origin of the curve is traced to an article that Rundle wrote with I. B. Hales in 1960. A review of the Hales and Rundle article, however, finds neither the familiar figure nor a description of Graves ophthalmopathy’s untreated chronologic course.

In some articles, such as a thoughtful review by Wiersinga both the 1945 and 1960 studies are referenced, but, in that particular article, Rundle’s curve is depicted as an inverse of what is commonly recognized today. So what is Rundle’s curve, and where did it originate?





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