Transient gestational hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of autism. We investigated the association between maternal hypothyroxinemia (gestational weeks 6–18) and autistic symptoms in children.
Association of gestational maternal hypothyroxinemia and increased autism risk
GC Román, A Ghassabian, JJ Bongers-Schokking, VWV Jaddoe, A Hofman, YB de Rijke, FC Verhulst,
H Tiemeier - Article first published online: 13 aug 2013. DOI: 10.1002/ana.23976. Annals of Neurology
Autism four times likelier when mother's thyroid is weakened
Houston Methodist, 13 aug 2013
Interview met Henning Tiemeier in NRC
Schildklier en zwangerschap: Generation R op Schildkliertje
Erasmus MC Rotterdam
Neurobiological pathways to childhood psychopathology - proefschrift dr. Akhgar Ghassabian
Onderzoeksresultaten Generation R op PubMed
Methods
The mother-and-child cohort of the Generation R Study (Rotterdam, the Netherlands) began prenatal enrollment between 2002 and 2006. At a mean gestational age of 13.4 weeks (standard deviation = 1.9, range = 5.9–17.9), maternal thyroid function tests (serum thyrotropin [TSH], free thyroxine [fT4], and thyroid peroxidase [TPO] antibodies) were assessed in 5,100 women. We defined severe maternal hypothyroxinemia as fT4 < 5th percentile with normal TSH. Six years later, parents reported behavioral and emotional symptoms in 4,039 children (79%) using the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist and/or the Social Responsiveness Scale (SRS). We defined a probable autistic child by a PDP score > 98th percentile and SRS score in the top 5% of the sample (n = 81, 2.0%).The association emerged from a study of more than
4,000 Dutch mothers and their children,
and it supports a growing view that autism spectrum disorders
can be caused by a lack of maternal thyroid hormone,
4,000 Dutch mothers and their children,
and it supports a growing view that autism spectrum disorders
can be caused by a lack of maternal thyroid hormone,
which past studies have shown is crucial to the migration
of fetal brain cells during embryo development.
Reacties
Een reactie posten