Natural history of subclinical hypothyroidism in children and adolescents and potential effects of replacement therapy: a review
A Monzani, F Prodam, A Rapa, S Moia, V Agarla, S Bellone and G Bona
ObjectiveSubclinical hypothyroidism (SH) is quite common in children and adolescents. The natural history of this condition and the potential effects of replacement therapy need to be known to properly manage SH. The aim of this review is to analyze:
- the spontaneous evolution of SH, in terms of the rate of reversion to euthyroidism, the persistence of SH, or the progression to over hypothyroidism; and
- the effects of replacement therapy, with respect to auxological data, thyroid volume, and neuropsychological functions.