woensdag 24 februari 2016

Treatment of severe thyroid function disorders and changes in body composition

Hyper- and hypothyroidism are accompanied by altered metabolic rate, thermogenesis, and body weight. The aim of this study was to estimate the relation between treatment-induced changes in thyroid function, and the accompanying body composition in patients with either severe hypo- or hyperthyroidism.

Treatment of severe thyroid function disorders and changes in body composition
M Ruchała, A Stangierski, T Krauze, J Moczko, P Guzik

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Body composition analysis and hormonal assessment were measured at the initial diagnosis of thyroid disorder, after 3-month treatment and finally after complete recovery from hyperthyroidism (n=18) or hypothyroidism (n=27). Nonparametric Spearman correlation was used to analyze the relation between thyroid hormones and body composition as well as their respective changes.

Results

The applied treatment significantly reduced total body weight, with a simultaneous loss in muscle, water and fat mass in hypothyroid patients, whereas in hyperthyroid patients it caused a weight gain, mainly due to an increase in fat mass. Total body weight and fat mass were significantly correlated with thyroid hormones’ concentrations in all patients. Changes of fat, water or muscle masses were strongly correlated with the changes in patients’ hormonal status.

Conclusions

Body composition is related to the concentration of thyroid hormones in thyroid dysfunction. Treatment-induced changes in thyroid hormones concentrations are correlated with the magnitude of the change of body weight, including muscle, water and fat amount.

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