woensdag 4 december 2013

Over anatabine, roken, tabak, ziekte van Hashimoto en antistoffen

Hashimoto’s thyroiditis is less prevalent in tobacco smokers. Anatabine, an alkaloid found in Solanaceae plants including tobacco, has been reported to ameliorate a mouse model of Hashimoto’s thyroiditis.

Anatabine supplementation decreases thyroglobulin antibodies in patients with chronic lymphocytic autoimmune (Hashimoto’s) thyroiditis: A randomized controlled clinical trial
LR Schmeltz, TC Blevins, SL Aronoff, K Ozer, JD Leffert, MA Goldberg, BS Horowitz, RH Bertenshaw,
P Troya, AE Cohen, RK Lanier, C Wright

Roken en autoimmuun schildklierziektes: het net sluit zich

Objective

The effects of anatabine in patients with Hashimoto’s thyroiditis.

Design, Setting, Patients, and Intervention

Double-blind, randomized, placebo-controlled multi-site study. A total of 146 patients (70 treated with anatabine, and 76 placebo) completed the study. Approximately 50% of patients in each group were on levothyroxine medication. Anatabine lozenges (9–24 mg/day) or placebo, each containing vitamins A and D3, were administered orally 3 times a day for three months.

Main Outcome Measures

Assessment of serum thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb). Safety was assessed though adverse events (AEs), clinical laboratory evaluations, and vital sign measurements.

Results

Anatabine treated patients had a significant reduction in absolute serum TgAb levels from baseline by study end relative to those on placebo (p = 0.027); however, there were no significant changes or differences in treatment group means for TPOAb or TgAb. Mean (± SD) TgAb values decreased by 46.2 (± 101.1) and 3.9 (± 83.9) WHO units for the anatabine and placebo groups, respectively. Significantly more patients had a drop in TgAb in the anatabine than placebo group. Overall the anatabine supplement was safe and well tolerated, although significantly more patients in the anatabine group reported AEs.

Conclusions

These results demonstrate an immunological effect of anatabine on TgAb levels. Further studies are warranted to dissect longer-term effects and possible actions of anatabine on the course of Hashimoto’s thyroiditis.


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