Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery:
the Generation R study
TIM Korevaar, S Schalekamp-Timmermans, YB de Rijke, WE Visser, W Visser, SMPF de Muinck Keizer-Schrama, A Hofman, HA Ross, H Hooijkaas, H Tiemeier, JJ Bongers-Schokking, VWV Jaddoe, TJ Visser, EAP Steegers, M Medici en RP Peeters
DesignSerum TSH, FT4, T4 and TPO-antibodies (TPOAb) were determined during early pregnancy in 5971 pregnant women from the Generation R study. Data were available on maternal age, parity, smoking, socio-economic status, ethnicity, maternal anthropometrics and urinary iodine levels.
Tim Korevaar presenteerde dit onderzoek op het ETA schildkliercongres in Leiden,
zie Abstracts, Oral Presentation 9 (OP9), pagina 78
- Of all women, 5.0% had a premature delivery (before 37 weeks), 4.4% had a spontaneous premature delivery and 1.4% a very premature delivery (before 34 weeks).
- High TSH levels and subclinical hypothyroidism were associated with premature delivery but not with spontaneous premature delivery.
- Maternal hypothyroxinemia was associated with a 2.5-fold increased risk of premature delivery, a 3.4-fold increased risk of spontaneous premature delivery and a 3.6-fold increased risk of very premature delivery.
- TPOAb positivity was associated with a 1.7-fold increased risk of premature delivery, a 2.1-fold increased risk of spontaneous premature delivery and a 2.5-fold increased risk of very premature delivery.
- These effects remained similar after correction for TSH/FT4 levels.
ConclusionsHypothyroxinemia and TPOAb positivity are associated with an increased risk of premature delivery. The increased risk in TPOAb positive women seems to be independent of thyroid function.
- Onderzoeksresultaten Generation R op PubMed
- Generation R op Schildkliertje
- Meer voorlichting vereist rond zwangerschap en schildklier