The recent recognition that the essential trace element selenium is incorporated as selenocysteine in all three deiodinases has decisively confirmed the clear-cut link between selenium and thyroid function. It has additionally been established that the thyroid contains more selenium than any other tissue and that selenium deficiency aggravates the manifestation of endemic myxedematous cretinism and autoimmune thyroid disease.
Selenium and the Thyroid: A Close-Knit Connection
Leonidas H. Duntas
Endocrine Unit, Evgenidion Hospital, University of Athens, Medical School, 115 28 Athens, Greece