woensdag 1 februari 2012

Individual TSH and thyroxine (T4) levels vary within the wide population range

When compared with the normal reference TSH range established by the NHANES III, TSH levels within the general population vary widely, with 95% falling between 0.45 and 4.0 mIU/L. This variation is probably due to age, gender, and comorbidities or drugs that interfere with normal thyroid function. Individual TSH and thyroxine (T4) levels vary within the wide population range. Of note, small nonpersistent increases in TSH may result in a misdiagnosis of mild thyroid failure in some individuals with TSH levels near the upper edge of the normal range.


In addition, TSH is secreted from the pituitary in a periodic, diurnal manner, with TSH levels generally higher in the morning and lower in the late afternoon and evening hours. Thus, a single TSH measurement may not provide an accurate representation of a patient’s TSH range. Repeat TSH testing should be carried out consistently, with measurements taken at the same time of day, in order to determine an individual’s TSH range and to properly diagnose thyroid dysfunction.

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